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Compiled from SEC Form N-PX filings and SPYRE THERAPEUTICS INC.’s Form 8-K, filed June 2, 2025 (Item 5.07 on EDGAR). Page generated October 18, 2026.
Meeting of May 29, 2025: 5 items on SPYRE THERAPEUTICS INC.’s Form 8-K, filed June 2, 2025: 2 approved · 3 without a stated outcome.
None.
Material dissent: a director nominee under 80% of the votes cast, say-on-pay under 70%, any other item the board put forward under 80%, or a shareholder proposal with more than 50%, on the company’s own Form 8-K tally. How this is decided
Proxy season: 2024-2025 2025-2026
Explore SPYRE THERAPEUTICS INC. in the interactive database Compare manager voting policies
These tallies are SPYRE THERAPEUTICS INC.’s own, as disclosed to the U.S. Securities and Exchange Commission on Form 8-K, filed June 2, 2025 (Item 5.07, “Submission of Matters to a Vote of Security Holders”). They cover every share voted at the meeting, not just the funds that file Form N-PX.
| Ballot item | For | Against | Abstain | Withheld | Broker non-votes | Support (of votes cast) | Reported outcome | Voting standard |
|---|---|---|---|---|---|---|---|---|
| Elect Director: Peter Harwin | 38,196,060 | -- | -- | 7,977,323 | 3,120,432 | 83% | Not verified | — |
| Elect Director: Michael Henderson, M.D. | 45,441,918 | -- | -- | 731,465 | 3,120,432 | 98% | Not verified | — |
| Elect Director: Sandra Milligan, M.D., J.D. | 37,612,795 | -- | -- | 8,560,588 | 3,120,432 | 81% | Not verified | — |
| 2. On a non-binding, advisory basis, the compensation of the Company's named executive officers | 42,930,720 | 3,144,040 | 98,623 | -- | 3,120,432 | 93% | Approved | — |
| 3. The appointment of KPMG LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025 | 49,227,863 | 57,123 | 8,829 | -- | 0 | 99.8% | Approved | — |
Source: SPYRE THERAPEUTICS INC., Form 8-K, filed with the SEC on June 2, 2025 — read the filing on EDGAR.
Each item below shows how the 152 asset managers that disclosed a SPYRE THERAPEUTICS INC. vote in their SEC Form N-PX filings actually voted. Share totals are the shares those managers' funds voted, summed across every fund they report.
Combines 4 wordings of this item as funds reported it.
98% Majority: yes · of votes cast
Description as filed by funds: Election of Class III Directors for terms expiring in 2028: Michael Henderson, M.D.
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Michael Henderson, M.D.”): 45,441,918 for, 731,465 withheld, per its Form 8-K filed June 2, 2025 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item.
Reported outcome: not verified — the filing’s own statement of the outcome could not be identified for this item.
Support: 98% of votes cast — FOR ÷ (FOR + WITHHELD); abstentions and broker non-votes are excluded.
The 52 asset managers below reported 14,802,981 for, 235,888 withheld, 166,327 abstained.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 266,534 | 0 | 0 | 0 | For |
| State Street | 196,276 | 0 | 0 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 0 | 133,433 | Withhold |
| Victory Capital | 123,032 | 0 | 0 | 0 | For |
| Equitable | 68,907 | 0 | 0 | 36,230 | Mixed |
| RBB FUND, INC. | 26,005 | 0 | 0 | 51,844 | Mixed |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 50,698 | 0 | 0 | 0 | For |
| TRUST FOR PROFESSIONAL MANAGERS | 45,516 | 0 | 0 | 0 | For |
| Jackson National | 43,688 | 0 | 0 | 0 | For |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 21,553 | 0 | 0 | 0 | For |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Combines 4 wordings of this item as funds reported it.
83% Majority: yes · of votes cast
Description as filed by funds: Election of Class III Directors for terms expiring in 2028: Peter Harwin
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Peter Harwin”): 38,196,060 for, 7,977,323 withheld, per its Form 8-K filed June 2, 2025 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item.
Reported outcome: not verified — the filing’s own statement of the outcome could not be identified for this item.
Support: 83% of votes cast — FOR ÷ (FOR + WITHHELD); abstentions and broker non-votes are excluded.
The 52 asset managers below reported 13,697,468 for, 770,668 withheld, 737,060 abstained.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 17,631 | 0 | 468,196 | 0 | Abstain |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 0 | 0 | 0 | 266,534 | Withhold |
| State Street | 196,043 | 0 | 0 | 233 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 0 | 133,433 | Withhold |
| Victory Capital | 12 | 0 | 0 | 123,020 | Withhold |
| Equitable | 105,137 | 0 | 0 | 0 | For |
| RBB FUND, INC. | 0 | 0 | 0 | 77,849 | Withhold |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 894 | 0 | 0 | 49,804 | Withhold |
| TRUST FOR PROFESSIONAL MANAGERS | 0 | 0 | 45,516 | 0 | Abstain |
| Jackson National | 0 | 0 | 43,688 | 0 | Abstain |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 0 | 0 | 0 | 22,194 | Withhold |
| John Hancock | 8,220 | 0 | 13,333 | 0 | Mixed |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Combines 4 wordings of this item as funds reported it.
81% Majority: yes · of votes cast
Description as filed by funds: Election of Class III Directors for terms expiring in 2028: Sandra Milligan, M.D., J.D.
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Sandra Milligan, M.D., J.D.”): 37,612,795 for, 8,560,588 withheld, per its Form 8-K filed June 2, 2025 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item.
Reported outcome: not verified — the filing’s own statement of the outcome could not be identified for this item.
Support: 81% of votes cast — FOR ÷ (FOR + WITHHELD); abstentions and broker non-votes are excluded.
The 52 asset managers below reported 13,455,733 for, 1,012,403 withheld, 737,060 abstained.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 17,631 | 0 | 468,196 | 0 | Abstain |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 0 | 0 | 0 | 266,534 | Withhold |
| State Street | 486 | 0 | 0 | 195,790 | Withhold |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 0 | 133,433 | Withhold |
| Victory Capital | 12 | 0 | 0 | 123,020 | Withhold |
| Equitable | 68,907 | 0 | 0 | 36,230 | Mixed |
| RBB FUND, INC. | 0 | 0 | 0 | 77,849 | Withhold |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 0 | 0 | 0 | 50,698 | Withhold |
| TRUST FOR PROFESSIONAL MANAGERS | 0 | 0 | 45,516 | 0 | Abstain |
| Jackson National | 0 | 0 | 43,688 | 0 | Abstain |
| Lincoln Financial | 0 | 0 | 0 | 29,700 | Withhold |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 8,220 | 0 | 13,333 | 0 | Mixed |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Combines 7 wordings of this item as funds reported it.
93% Approved · of votes cast
Description as filed by funds: TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.
SPYRE THERAPEUTICS INC.’s own tally for this item (“2. On a non-binding, advisory basis, the compensation of the Company's named executive officers”): 42,930,720 for, 3,144,040 against — passed, per its Form 8-K filed June 2, 2025 (Item 5.07).
Reported outcome: Approved, in the filing’s own words: “Proposal No. 2 The Company's stockholders approved, on a non-binding, advisory basis, the compensation of the Company's named executive officers.”
Support: 93% of votes cast — FOR ÷ (FOR + AGAINST); abstentions and broker non-votes are excluded.
Fund voting reports and institutional-manager reports both cover this item. An institutional manager can report shares that a fund it advises also reports, so the two are shown separately below and never added together, and their sum is not shown (fund and manager reports combined may count the same shares twice).
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 0 | 2,741,678 | 0 | 0 | Against |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 266,534 | 0 | 0 | 0 | For |
| State Street | 196,223 | 53 | 0 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 166,327 | 0 | 0 | 0 | For |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 133,433 | 0 | 0 | 0 | For |
| Victory Capital | 123,032 | 0 | 0 | 0 | For |
| Equitable | 105,137 | 0 | 0 | 0 | For |
| RBB FUND, INC. | 77,849 | 0 | 0 | 0 | For |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 50,698 | 0 | 0 | 0 | For |
| TRUST FOR PROFESSIONAL MANAGERS | 45,516 | 0 | 0 | 0 | For |
| Jackson National | 43,688 | 0 | 0 | 0 | For |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 0 | 22,239 | 0 | 0 | Against |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 21,553 | 0 | 0 | 0 | For |
Fund voting reports, all 52 managers: 12,422,198 for, 2,782,998 against. Showing the 25 largest; see all in the interactive database.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 7,664,103 | 0 | 0 | 0 | For |
| Fairmount Funds Management LLC | 4,018,101 | 0 | 0 | 0 | For |
| RTW INVESTMENTS, LP | 3,583,727 | 0 | 0 | 0 | For |
| Capital Group | 0 | 2,741,678 | 0 | 0 | Against |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,856,436 | 0 | 0 | 0 | For |
| PERCEPTIVE ADVISORS LLC | 1,311,814 | 0 | 0 | 0 | For |
| BRAIDWELL LP | 1,139,682 | 0 | 0 | 0 | For |
| GEODE CAPITAL MANAGEMENT, LLC | 1,049,384 | 0 | 0 | 0 | For |
| Commodore Capital LP | 1,010,289 | 0 | 0 | 0 | For |
| PICTET ASSET MANAGEMENT SA | 983,369 | 0 | 0 | 0 | For |
| BlackRock | 949,634 | 606 | 0 | 0 | For |
| Wellington | 917,657 | 0 | 0 | 0 | For |
| State Street | 814,719 | 86 | 0 | 0 | For |
| FRANKLIN ADVISERS INC | 760,615 | 0 | 0 | 0 | For |
| Paradigm Biocapital Advisors LP | 630,473 | 0 | 0 | 0 | For |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 0 | 0 | 0 | For |
| Janus Henderson | 591,627 | 0 | 0 | 0 | For |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 460,400 | 0 | 0 | 0 | For |
| Charles Schwab | 382,160 | 0 | 0 | 0 | For |
| Blackstone Inc. | 374,299 | 0 | 0 | 0 | For |
| EMERALD MUTUAL FUND ADVISERS TRUST | 351,604 | 0 | 0 | 0 | For |
| Siren, L.L.C. | 314,299 | 0 | 0 | 0 | For |
| Victory Capital | 267,385 | 0 | 0 | 0 | For |
| T. Rowe Price | 251,143 | 0 | 0 | 0 | For |
| Affinity Asset Advisors, LLC | 239,269 | 0 | 0 | 0 | For |
Institutional-manager reports, all 115 managers: 32,362,824 for, 3,012,912 against, 1,834 abstained. Showing the 25 largest; see all in the interactive database.
99.8% Approved · of votes cast
Description as filed by funds: TO RATIFY THE APPOINTMENT OF KPMG LLP AS THE COMPANY'S INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 2025.
SPYRE THERAPEUTICS INC.’s own tally for this item (“3. The appointment of KPMG LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025”): 49,227,863 for, 57,123 against — passed, per its Form 8-K filed June 2, 2025 (Item 5.07).
Reported outcome: Approved, in the filing’s own words: “Proposal No. 3 The Company's stockholders ratified the appointment of KPMG LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025.”
Support: 99.8% of votes cast — FOR ÷ (FOR + AGAINST); abstentions and broker non-votes are excluded.
The 52 asset managers below reported 15,204,611 for, 585 against.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 266,534 | 0 | 0 | 0 | For |
| State Street | 196,276 | 0 | 0 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 166,327 | 0 | 0 | 0 | For |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 133,433 | 0 | 0 | 0 | For |
| Victory Capital | 123,032 | 0 | 0 | 0 | For |
| Equitable | 105,137 | 0 | 0 | 0 | For |
| RBB FUND, INC. | 77,849 | 0 | 0 | 0 | For |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 50,698 | 0 | 0 | 0 | For |
| TRUST FOR PROFESSIONAL MANAGERS | 45,516 | 0 | 0 | 0 | For |
| Jackson National | 43,688 | 0 | 0 | 0 | For |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 21,553 | 0 | 0 | 0 | For |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Ranked separately for each type of Form N-PX report. An institutional manager can report shares that a fund it advises also reports, so the two tables can list the same shares and are never added together. Each is ranked by the shares voted on the item that the most managers of that type reported, shown as a share of the 60,275,561 shares outstanding at the time of that meeting.
| # | Asset manager | % of shares outstanding |
|---|---|---|
| 1 | Fidelity | 9.85% |
| 2 | Vanguard | 4.70% |
| 3 | Capital Group | 4.55% |
| 4 | BlackRock | 1.10% |
| 5 | Bridge Builder Trust | 0.81% |
| 6 | Charles Schwab | 0.63% |
| 7 | FRANKLIN STRATEGIC SERIES | 0.45% |
| 8 | DRIEHAUS MUTUAL FUNDS | 0.44% |
| 9 | State Street | 0.33% |
| 10 | Hartford | 0.31% |
| # | Asset manager | % of shares outstanding |
|---|---|---|
| 1 | Fidelity | 12.72% |
| 2 | Fairmount Funds Management LLC | 6.67% |
| 3 | RTW INVESTMENTS, LP | 5.95% |
| 4 | Capital Group | 4.55% |
| 5 | DRIEHAUS CAPITAL MANAGEMENT LLC | 3.08% |
| 6 | PERCEPTIVE ADVISORS LLC | 2.18% |
| 7 | BRAIDWELL LP | 1.89% |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | 1.74% |
| 9 | Commodore Capital LP | 1.68% |
| 10 | PICTET ASSET MANAGEMENT SA | 1.63% |
As disclosed to the SEC in Form 13F (quarter-end holdings of 30 large managers), Schedules 13D and 13G (beneficial ownership above 5%) and the company’s own proxy statement (DEF 14A). Each row names its form.
| Holder | % outstanding | Disclosure |
|---|---|---|
| FMR (Fidelity) | 15.00% | 13F |
| Peter Harwin | 14.96% | 13D |
| FMR LLC | 12.65% | DEF14A |
| Tomas Kiselak | 11.18% | DEF14A |
| Fairmount Healthcare Fund II L.P. | 10.36% | DEF14A |
| Perceptive Advisors LLC | 7.17% | 13G |
| RTW Investments, LP | 6.01% | 13G |
| BlackRock | 5.93% | 13F |
| Peter Deutsch | 5.89% | DEF14A |
| Vanguard Group | 4.81% | 13F |
Percentages above are of 60,275,561 shares outstanding, as reported by SPYRE THERAPEUTICS INC. on its Form 10-Q dated March 31, 2025 (see the filing on EDGAR). This is the count contemporaneous with the 2024-2025 meeting, not today’s. Each holding is as of its own filing, which may be dated before or after the meeting.
Every figure above is derived from filings made with the US Securities and Exchange Commission: Form N-PX, in which registered funds disclose how they voted every proxy and institutional managers disclose their votes on executive pay (say-on-pay, say-on-frequency and golden parachutes), and Form 8-K Item 5.07, in which the company reports its own meeting results. Shares outstanding are taken from SPYRE THERAPEUTICS INC.’s 10-Q dated March 31, 2025. This page is a static snapshot rebuilt weekly on October 18, 2026; a live search always shows the current data.
At SPYRE THERAPEUTICS INC.'s shareholder meeting held May 29, 2025, in the 2024-2025 proxy season, 152 asset managers reported how they voted on 5 ballot items in their SEC Form N-PX filings, covering 942 separate fund positions. On the most widely held item on that ballot — TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE… — SPYRE THERAPEUTICS INC.'s filing reports the proposal as approved, with 93% support of the votes cast (FOR divided by FOR plus AGAINST, the conventional basis for proxy support; abstentions, broker non-votes and unvoted shares are excluded because none of them took a side). Source: SPYRE THERAPEUTICS INC.'s Form 8-K, Item 5.07, filed with the U.S. Securities and Exchange Commission on June 2, 2025.
SPYRE THERAPEUTICS INC. proxy season coverage: 2024-2025 (this page) · 2025-2026.
Download data (CSV): ballot items · votes by manager · column guide.